News and Announcements
New NCI Biospecimen Evidence-Based Practices (NCI BEBP) NOW AVAILABLE!
The expert-vetted NCI BEBP details blood collection and processing procedures specifically tailored for miRNA analysis. View the BEBP on BBRB’s website and in the BRD!
Just Published!
Announcement of a new NCI Biospecimen Evidence-Based Practices on blood collection and processing for miRNA analysis is available ahead of print in Clinical Chemistry Laboratory Medicine.
We're at the ISBER 2023 Annual Meeting!
Stop by and learn more about:
NCI Biospecimen Evidence-Based Practices: Poster PA-06, Session 1 on Wednesday, May 3rd from 6:00-7:00 pm
Biospecimen and Data Resources from the Cancer Moonshot Biobank: Poster PG-07, Session 2 on Thursday, May 4 from 6:00 -7:00 pm
The Most Downloaded SOPs in 2022
The top 5 most downloaded SOPs from the BRD's SOP Library were
- Tissue Processing (UCHC Tissue Repository)
- Labeling (NIEHS)
- Vaginal Swab Collection (GAPPS Repository)
- Cell Viability Testing with Trypan Blue Exclusion Method (NIEHS)
- RNA Isolation (CC GMI)
Contribute to the BRD SOP Library
SOPs have been downloaded from the Biospecimen Research Database’s SOP Library more than 1 million times!
Share SOPs used by your repository or biobank in NCI’s BRD today.
New Findings from NCI's BPV Program have been Published
A new study from NCI's Biospecimen Pre-analytical Variables (BPV) Program is now available that reports effects on aCGH results in FFPE RCC specimens after a delay to fixation ≥3 h or a fixation time of 72 h.
New SOPs were Recently Added to the BRD SOP Library
New Contributing SOP Sources Include:
- African Research Group for Oncology (ARGO)
- Indiana Clinical and Translational Sciences Institute (CTSI)
- Rare Kidney Disease Registry & Biobank Protocols (RKD Biobank)
The Most Downloaded SOPs from the BRD
The top 5 most downloaded SOPs from the BRD are:
Cell Viability Testing by the NIEHS
Laboratory Shipping Protocols by the NIEHS
Whole Blood Washing Method by the Immune Tolerance Network
Vaginal Swab Collection by the GAPPS Repository
New SOPs have been added to the BRD!
Click the links below to view SOPs added from each new Source organization.
University of Ottawa Heart Institute Biobank (UOHI Biobank)
Peripheral Neuropathy Research Registry (PNRR)
New Paper Suggestion!
Jeffs 2019: Our newest Paper Suggestion reports a mass spec marker of thaw duration for plasma/serum. https://lnkd.in/d8NQcpRC
New SOPs in the BRD!
Click the links below to view the new SOPs that have recently been added to the BRD.
Columbia Center for Translational Immunology (CCTI) Biobank Core
European Association of Urology Research Foundation (EAU)
The JHC Editor's Choice Article for May is a BPV Program Study
The May Editor's Choice Article for Journal of Histochemistry and Cytochemistry is "Impact of Preanalytical Factors on the Measurement of Tumor Tissue Biomarkers Using Immunohistochemistry" by Bagchi et al.
New Study from NCI’s BPV Program Now Available!
Effects of delay-to-fixation and time-in-fixative on IHC staining of cancer biomarkers
SOPs Related to SARS-CoV2 (COVID-19)
A compendium of SOPs related to the collection and testing for the novel 2019 coronavirus (SARS-CoV2, COVID-19) is available: https://brd.nci.nih.gov/brd/sop-compendium/show/1361.
Most Popular SOPs in 2020
The top 5 most downloaded SOPs from the BRD in 2020 were supplied by:
NIEHS: https://brd.nci.nih.gov/brd/sop/show/941
NIEHS: https://brd.nci.nih.gov/brd/sop/show/944
CDC: https://brd.nci.nih.gov/brd/sop/show/563
NIEHS: https://brd.nci.nih.gov/brd/sop/show/945
GAPPS Repository: https://brd.nci.nih.gov/brd/sop/show/890
New SOP Compendiums on Snap-freezing Tissue
Two new compendiums of SOPs related to snap-freezing tissue specimens are now available:
For SOPs that specify dry ice CLICK HERE.
For SOPs that specify liquid nitrogen CLICK HERE.
The NCI BEBP document for snap-freezing tissue can be found HERE.
ISBER 2020 Electronic Posters Now Available!
CLICK HERE to view the ISBER 2020 electronic poster on the BRD.
View other's electronic posters on the ISBER 2020 main page HERE.
SOPs Related to SARS-CoV2 (COVID19)
A new compendium of SOPs related to the collection and testing for the novel 2019 coronavirus (SARS-CoV2, COVID19) is now available: https://brd.nci.nih.gov/brd/sop-compendium/show/1361.
LAST WEEK to participate in the BRD Survey
The BRD user survey will close this Friday, 7/31/20. Your responses will help us better tailor the BRD's content to the needs of the community. Consider taking the short 6 question survey by CLICKING HERE.
BRD Visitor Survey is Now Open!
Please take a short survey on how you're using SOPs from the BRD by CLICKING HERE.
NEW Expert-Vetted BEBP Now Available!
A new Expert-Vetted Biospecimen Evidence-Based Practices document on blood collection and processing for cfDNA analysis is now available.
Click here to view the BEBP document
Click here to view the accompanying publication
Most Popular SOPs in 2019
The top 5 most downloaded SOPs in the BRD in 2019 were supplied by:
NIEHS: https://brd.nci.nih.gov/brd/sop/show/941
NIEHS: https://brd.nci.nih.gov/brd/sop/show/944
NIEHS: https://brd.nci.nih.gov/brd/sop/show/945
CC GMI: https://brd.nci.nih.gov/brd/sop/show/823
GAPPS Repository: https://brd.nci.nih.gov/brd/sop/show/890
Most Popular SOPs in 2018
The top 5 most downloaded SOPs in the BRD in 2018 were supplied by:
NIEHS: https://brd.nci.nih.gov/brd/sop/show/941
NIEHS: https://brd.nci.nih.gov/brd/sop/show/944
GAPPS Repository: https://brd.nci.nih.gov/brd/sop/show/890
NIEHS: https://brd.nci.nih.gov/brd/sop/show/945
CC GMI: https://brd.nci.nih.gov/brd/sop/show/823
New Article Published from NCI's Biospecimen Pre-analytical Variables (BPV) Program
A new article from NCI's BPV Program is now available that reports deleterious effects of formalin-fixation and delays to fixation on RNA and miRNA-Seq profiles.
View the BRD Curation at https://brd.nci.nih.gov/brd/paper/sci-rep/2019/deleterious-effects-of-formalin-fixation-and-delays-to-fixation/129450
View the PubMed Abstract at https://www.ncbi.nlm.nih.gov/pubmed/31061401
2019 Annual ISBER Meeting
Be sure to check out the presentation by NCI/BBRB's Helen Moore this Friday during the Biospecimen Science Session (4C), "The Evidence Base for Controlling and Mitigating Pre-analytical Variation".
2019 Annual ISBER Meeting
At ISBER? Stop by and visit the BRD poster on quality assessment methods represented in the SOP Library (#PBR16).
New Article Published from NCI's Biospecimen Pre-analytical Variables Program
Results from NCI's Biospecimen Pre-analytical Variables (BPV) Program on effects of a delay to fixation and time in fixative on DNA and RNA quality have been published. View the article at https://www.ncbi.nlm.nih.gov/pubmed/30785788.
SOPs from the Biospecimen Pre-analytical Variables (BPV) Program are now available!
View them at: https://brd.nci.nih.gov/brd/sop-compendium/show/1181.
New SOPs added to the BRD!
SOPs from the Prostate Cancer Biorepository Network (PCBN) were added to the BRD. View them at: https://brd.nci.nih.gov/brd/sop-compendium/show/1141
New Expert-Vetted BEBP Now Available
A new Expert-Vetted Biospecimen Evidence-Based Practices document on nucleic acid extraction from FFPE tissue blocks is now available in the BRD's SOP library. Visit the publication announcing the release at https://www.ncbi.nlm.nih.gov/pubmed/29920119.
ISBER 2018 Meeting
Don't miss BBRB's presentation on comparisons among SOPs from the BRD's SOP Library during this Wednesday's (5/23/18) morning session at the ISBER 2018 Annual Meeting.
Later, stop by and visit the ISBER Tool Bench at 3:30 pm (Wednesday, 5/23/18) to learn more about the BRD and how it may be of use to you.
AACR Annual Meeting 2018
Stop by and visit BBRB's poster (Abstract #4763) on the BRD and the Biospecimen Evidence-Based Practices document series at the AACR Annual Meeting 2018 on 4/17.
The 4th edition of the ISBER Best Practices is Now Available!
The newest edition of the ISBER Best Practices was released on January 31, 2018. View the document at http://www.isber.org/?page=BPR.
Most Popular SOPs in 2017
The top 5 most downloaded SOPs in the BRD in 2017 were supplied by:
NIEHS: https://brd.nci.nih.gov/brd/sop/show/944
NIEHS: https://brd.nci.nih.gov/brd/sop/show/941
GAPPS Repository: https://brd.nci.nih.gov/brd/sop/show/890
UCHC Tissue Repository: https://brd.nci.nih.gov/brd/sop/show/841
NIEHS: https://brd.nci.nih.gov/brd/sop/show/945
New Review from BBRB: Understanding preanalytical variables and their effects on clinical biomarkers of oncology and immunotherapy
The review, which appears in a special issue of Seminars in Cancer Biology, summarizes reported effects of preanalytical variability on immunologically relevant biomarkers. Find it here.
2017 Global Biobank Week Conference
Stop by and visit BBRB's poster on the NCI's Biospecimen Evidence-Based Practices (BEBP) document series at the Global Biobank Meeting in Stockholm, Sweden September 13th-15th.
ISBER 2017 Annual Meeting
Stop by and visit BBRB's poster on the BRD and the Biospecimen Evidence-Based Practices document series at the ISBER 2017 Annual Meeting on May 11th.
Most Popular SOPs in 2016
The top 5 most downloaded SOPs in the BRD in 2016 were supplied by
NIEHS: https://brd.nci.nih.gov/brd/sop/show/944, https://brd.nci.nih.gov/brd/sop/show/945
CC GMI: https://brd.nci.nih.gov/brd/sop/show/823
GAPPS Repository: https://brd.nci.nih.gov/brd/sop/show/890
UCHC Tissue Repository: https://brd.nci.nih.gov/brd/sop/show/841
New SOPs were submitted from Q-CROC
New SOPs from the Consortium de Recherche en Oncologie Clinique du Québec (Q-CROC) were added to the BRD. View them at https://brd.nci.nih.gov/brd/sop-compendium/show/601.
ISBER 2016 Regional Meeting
Visit BBRB's poster on the BRD at the ISBER Regional Meeting in Bethesda, MD on Nov 7th and 8th. http://meetings.isber.org/regional2016/
New SOPs added!
SOPs from NIH's Epidemiology & Genomics Research Program were added to the BRD. View them at http://brd.nci.nih.gov/brd/sop-compendium/show/501
Did you know that PubMed links out to the BRD?
Look for a link to the BRD on the bottom of the PubMed abstract page, under "LinkOut-more resources".
New Review from BBRB. Accuracy of Molecular Data Generated with FFPE Biospecimens: Lessons from the Literature
The review appears in Cancer Research's OnlineFirst section, and both summarizes the challenges associated with molecular analysis of FFPE biospecimens as well as highlights analytical techniques and parameters that result in strong concordance with a fresh or frozen cohort.
Click here to read the article.
ISBER Biospecimen Science Literature Compilation
The ISBER Biospecimen Science Working Group has compiled hundreds of biospecimen science references from both the clinical and the environmental sectors: click here!
New Review from BBRB: How well do you know your FFPE specimen?
A new review summarizing the effects of FFPE processing factors on nucleic acid, protein, and morphological endpoints appears in the November 2014 issue of Arch Pathol Lab Med. The review was drafted using references housed in the BRD.
Click here to read the article.
Click here to read the accompanying editorial.
NCI Biospecimen Evidence-Based Practices now Available
NCI BEBPs are literature-annotated procedural guidelines based upon entries contained within the BRD. The first BEBP in an anticipated series is now available at biospecimens.cancer.gov/resources/bebp.asp and addresses snap-freezing of post-surgical tissue biospecimens.
Cited By...
The BRD has been cited as a reference in
- Basik, M., et. al. (2013). "Biopsies: next-generation biospecimens for tailoring therapy." Nat Rev Clin Oncol 10(8): 437-45.
- McShane, L. M., et.al. (2013). "Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration." BMC Med 11: 220.
- Hewitt, R. E. (2011). "Biobanking: the foundation of personalized medicine." Curr Opin Oncol 23(1): 112-119.
- Baer, A. R. et. al. (2010). "Cancer genomics: conducting exemplary trials with biospecimen and biomarker components." J Oncol Pract 6(3): 164-167.
New Search Features Now Available
Browse by Analyte or Pre-analytical Factor, or increase search stringency by using the Advanced Search, which contains drop down menu options and a keyword search. Results of a Keyword Search can also be limited to studies that explored experimental comparisons by selecting the box on the Search Results page.