NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis

MALDI Glycan Analytical Validation (Stanford)   Add to my SOP compendium

BRD ID: 3,384

Source: CIMAC-CIDC Network Tier: SOP

Description

This assay analytical validation and performance report describes the methods used to validate a matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) method for the analysis of N-glycans in formalin-fixed, paraffin-embedded tissue. MALDI-IMS data from four kidney specimens were presented in conjunction with images of corresponding H&E stained FFPE sections in support of the accuracy, precision, robustness, and reproducibility of the assay. The report is used by the Cancer Immune Monitoring and Analysis Center (CIMAC) at Stanford University. It is a product of the Cancer Immune Monitoring and Analysis Center Cancer Immunologic Data Center Network (CIMAC-CIDC Network); https://dctd.cancer.gov/ResearchNetworks/cimacs_cidc_network.htm).

Documents for Download

508C_MALDI-Glycan_Validation_2024 final w coverpage.pdf [Size: 4499 KB]

Biospecimens
  • Tissue - Kidney
Diagnoses
  • Neoplastic - Carcinoma
  • Normal
  • Other diagnoses
  • General
Topics
  • Platform-specific Methodology

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