NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis

TCRseq: Repertoire TCRseq using RNA Analytical Performance (DFCI)   Add to my SOP compendium

BRD ID: 3,117

Source: CIMAC-CIDC Network Tier: SOP Number of times downloaded: 67

Description

This assay analytical validation and performance report describes the methods used to validate T-cell receptor (TCR) sequencing of bulk RNA using total RNA isolated from peripheral blood mononuclear cells (PBMCs) that were collected from healthy individuals. The document also presents data supporting the reported analytical sensitivity and reportable range. It is used by the Cancer Immune Monitoring and Analysis Center (CIMAC) at the Dana-Farber Cancer Institute. It is a product of the CIMAC and Cancer Immunologic Data Center Network (CIMAC-CIDC Network; https://dctd.cancer.gov/ResearchNetworks/cimacs_cidc_network.htm), a Cancer Moonshot Initiative.

Documents for Download

Analytical report_TCRseq RNA Bulk_06042019_DFCI_508_Final.pdf [Size: 627 KB]

Biospecimens
  • Cell - White Cells
Diagnoses
  • Normal
Topics
  • Platform-specific Methodology

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