NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis
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Receptor Occupancy for ISL SOP/Methods   Add to my SOP compendium

BRD ID: 2,508

Source: HANC Tier: SOP Number of times downloaded: 125

Description

This document describes the procedures used by the Office of HIV/AIDS Network Coordination (HANC) to quantify CCR5 and/or CCR2 receptor binding to an experimental drug by flow cytometry using fresh or frozen peripheral blood mononuclear cells isolated from EDTA blood collected from clinical trial participants. It is developed and maintained by the AIDS Clinical Trials Group (ACTG)/International Maternal Pediatric Adolescent AIDS Clinical Trials group (IMPAACT) Lab Tech Committee (LTC) and is available under the heading "Other SOPs" at https://www.hanc.info/labs/labresources/procedures/Pages/actgImpaactLabManual.aspx.

Documents for Download

CCR5 and CCR2 Receptor Occupancy Protocol.pdf [Size: 138 KB]
Biospecimens
  • Fluid - Blood
  • Cell - White Cells
Diagnoses
  • AIDS/HIV-related
Topics
  • Platform-specific Methodology

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