NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis

Performing Alloreactive ELISPOT assays   Add to my SOP compendium

BRD ID: 1,378

Source: Immune Tolerance Network Tier: SOP Number of times downloaded: 1115

Description

This document describes procedures for the preparation and analysis of cytokines secreted by PBMCs following alloantigen/antigen stimulation by Enzyme-linked immunospot assay (ELISPOT) including, T cell depletion and isolation of peripheral blood mononuclear cells (PBMC) using Ficoll Isoprep from spleen and isolation of antigen-presenting cells (APC) from whole blood. It is a product of the Immune Tolerance Network (ITN; https://www.immunetolerance.org/). Additional ITN SOPs are available at https://www.immunetolerance.org/researchers/lab-protocols.

Documents for Download

SOP_Performing Alloreactive ELISPOT Assays ELI 001 FIN.pdf [Size: 181 KB]

Biospecimens
  • Cell - White Cells
  • Tissue - Spleen
Diagnoses
  • General
  • Normal
Topics
  • Biospecimen Processing

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