Tissue shrinkage after fixation with formalin injection of prostatectomy specimens.

Author(s): Jonmarker S, Valdman A, Lindberg A, Hellström M, Egevad L

Publication: Virchows Arch, 2006, Vol. 449, Page 297-301

PubMed ID: 16909262 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of formalin injection versus conventional immersion on radical prostatectomy specimen volume and weight measurements.

   Summary of Findings:

   Specimens injected with 20 mL of formalin prior to immersion showed significantly less weight loss after final fixation than specimens fixed solely by immersion (5.8 versus 8.6% weight loss, p<0.001). However, method of fixative delivery had no significant effects on specimen shrinkage after fixation (4.5%) or on tumor volume.

   Biospecimens

   • Tissue - Prostate

   Preservative Types

   • Formalin

   Diagnoses:

   • Neoplastic - Carcinoma

   Platform:

   Analyte	Technology Platform
   Morphology	Light microscopy
   Cell count/volume	Macroscopic observation

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Preservation	Method of fixative delivery	Immersion Injection followed by immersion

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