Comparison of platelet activity measurements by use of arterial and venous blood sampling.

Author(s): Shah B, Sedlis SP, Mai X, Amoroso NS, Guo Y, Lorin JD, Berger JS

Publication: J Thromb Haemost, 2013, Vol. 11, Page 1922-4

PubMed ID: 23927560 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine whether differences in platelet counts, MPV, IPF, MPA, and LPA exist between venous and arterial blood and whether soluble P-selectin levels differ between plasma from venous and arterial blood. Sodium citrate plasma was frozen at -80 degrees C prior to soluble P-selectin analysis. Blood specimens intended for all other analyses were collected into K2EDTA and analyzed within one hour.

   Summary of Findings:

   Venous and arterial blood showed strong to very strong correlations in platelet counts, MPV, IPF, and LPA, but MPA in blood and soluble P-selectin levels in plasma were only modestly correlated between the two types of specimens (rho=0.65 and 0.68, respectively). For both of these analytes, median values were higher among the venous specimens than the arterial specimens.

   Biospecimens

   • Bodily Fluid - Blood
   • Bodily Fluid - Plasma

   Preservative Types

   • None (Fresh)
   • Frozen

   Diagnoses:

   • Diabetes Type 1
   • Diabetes Type 2
   • Coronary Artery Disease
   • Normal

   Platform:

   Analyte	Technology Platform
   Cell count/volume	Hematology/ auto analyzer
   Cell count/volume	Flow cytometry
   Protein	ELISA

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Aliquots and Components	Blood and blood products	Plasma Whole blood
   Biospecimen Preservation	Type of fixation/preservation	Frozen None (fresh)
   Biospecimen Acquisition	Anatomical location of blood draw	Artery Vein

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