Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Stability of atrial natriuretic peptide during storage at -20 degrees C.

Author(s): Buckley MG, Sagnella GA, MacGregor GA

Publication: J Hum Hypertens, 1996, Vol. 10, Page 431-2

PubMed ID: 8872814 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of frozen storage duration on levels of ANP in pooled plasma from healthy volunteers, and plasma from heart failure patients. The anticoagulant used in this study was unspecified.

   Summary of Findings:

   ANP levels in pooled plasma varied by 12.5% over the 28 weeks of the study, but the authors state that the analytical variability of the assay was 11%. Further, ANP levels in heart failure patients were not significantly different in plasma stored frozen for 6 months compared to levels measured in the corresponding fresh plasma specimens.

   Biospecimens

   • Bodily Fluid - Plasma
   • Bodily Fluid - Blood

   Preservative Types

   • Frozen
   • None (Fresh)

   Diagnoses:

   • Cardiovascular Disease
   • Normal

   Platform:

   Analyte	Technology Platform
   Peptide	Radioimmunoassay

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Preservation	Type of fixation/preservation	Frozen None (fresh)
   Storage	Storage duration	1-28 weeks 0 days 6 months
   Preaquisition	Diagnosis/ patient condition	Healthy Heart failure patient

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