Further evaluation of a new standard of efficacy for stored platelets.

Author(s): AuBuchon JP, Herschel L, Roger J

Publication: Transfusion, 2005, Vol. 45, Page 1143-50

PubMed ID: 15987360 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of collection method, storage and radiolabel on platelet recovery and survival.

   Summary of Findings:

   Platelets obtained using an apheresis unit that were retransfused on day 1 of storage had a 65.1% recovery rate with an average survival of 7.7 days. After 7 days of storage of platelets at 20-24 degrees C, the mean platelet recovery rate was 56.4%, and the mean survival decreased by 15.7% to 6.5 days. In a second study, manually separated and retransfused platelets showed a mean recovery rate of 59.5% after 1 day and 50.4% after 7 days. Further, the mean survival rate decreased from 8.8 days in platelets retransfused on day 1 to 6.7 days in platelets stored for 7 days. Generally, manual separation was associated with lower platelet recovery, but longer survival compared to apheresis. When platelets were radiolabelled with In111 or Cr51 and retransfused, there were no differences in mean recovery or survival rates between the two radiolabels.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal

   Platform:

   Analyte	Technology Platform
   Cell count/volume	Radioassay

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Storage	Storage duration	< 1 day 7 days
   Biospecimen Acquisition	Method of fluid acquisition	Apheresis Venipuncture
   Radioassay Specific	Detection method	In111 Cr51
   Biospecimen Aliquots and Components	Blood processing method	Apheresis Manual separation

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