Effects of blood collection conditions on ovarian cancer serum markers.
Author(s): Thorpe JD, Duan X, Forrest R, Lowe K, Brown L, Segal E, Nelson B, Anderson GL, McIntosh M, Urban N
Publication: PLoS One, 2007, Vol. 2, Page e1281
PubMed ID: 18060075 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
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Study Purpose
The purpose of this study was to determine the effects of anesthesia and time of collection with respect to day of surgery on levels of CA 125, prolactin, and MIF in serum from healthy volunteers and patients with ovarian, fallopian tube, and peritoneal cancer and other benign and non-neoplastic conditions.
Summary of Findings:
Prolactin levels were significantly increased in serum obtained after the administration of anesthesia on the day of surgery, whether from surgical control patients, benign control patients, or cancer patients, compared to levels measured in serum collected 1-39 days prior to surgery or from healthy controls. In contrast, CA 125 levels and MIF concentrations were significantly different between serum from healthy, surgical, or benign control patients and patients with cancer, regardless of whether the specimen was obtained with no anesthesia 1-39 days prior to surgery or after the administration of anesthesia on the day of surgery.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Not specified
- Normal
- Neoplastic - Benign
- Neoplastic - Carcinoma
Platform:
Analyte Technology Platform Protein ELISA Protein Immunoassay Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Preaquisition Anesthesia Collected after administration of anesthesia
Collected with no anesthesia
Biospecimen Acquisition Time of biospecimen collection On the day of surgery
1-39 days prior to surgery
Preaquisition Diagnosis/ patient condition Normal
Non-neoplastic condition requiring surgery
Benign condition requiring surgery
Malignant condition requiring surgery