NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis

Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.

Author(s): Taheri S, Lin L, Austin D, Young T, Mignot E

Publication: PLoS Med, 2004, Vol. 1, Page e62

PubMed ID: 15602591 PubMed Review Paper? No

Purpose of Paper

The purpose of this paper was to determine the effects of average nightly sleep, BMI, age and gender on metabolic markers in serum.

Conclusion of Paper

There was a curvilinear relationship between average nightly sleep and BMI. Ghrelin decreased and leptin increased with increasing average nightly sleep. Ghrelin, leptin, adiponectin, insulin and glucose levels were correlated with BMI and gender. Adiponectin and glucose increased with age. The authors report that storage of serum at -70 degrees C had a small effect on some variables, but no details were provided.

Studies

  1. Study Purpose

    The purpose of this study was to determine the effects of average nightly sleep, BMI, age and gender on metabolic markers in serum. Serum was stored at -70 degrees C for an unspecified time.

    Summary of Findings:

    There was a curvilinear relationship between average nightly sleep and BMI, with the lowest BMI found in individuals with an average of 7.7 h of nightly sleep. Ghrelin decreased and leptin increased with increasing average nightly sleep. Ghrelin, leptin, adiponectin levels were higher and insulin and glucose levels were lower in females than males. Further an increase in BMI correlated with a decrease in ghrelin and adiponectin levels and an increase in leptin, insulin and glucose levels. When average nightly sleep decreased from 8 h to 5 h, there was a 15.5% decrease in leptin, a 14.9% increase in ghrelin, and an increase in average BMI from 31.3 to 32.4. The authors report that storage of serum at -70 degrees C had a small effect on some variables, but no details were provided. Adiponectin and glucose increased with patient age.

    Biospecimens
    Preservative Types
    • Frozen
    Diagnoses:
    • Not specified
    • Hypertension
    • Diabetes Type 2
    Platform:
    AnalyteTechnology Platform
    Carbohydrate Clinical chemistry/auto analyzer
    Protein ELISA
    Protein Radioimmunoassay
    Peptide Radioimmunoassay
    Lipid Clinical chemistry/auto analyzer
    Pre-analytical Factors:
    ClassificationPre-analytical FactorValue(s)
    Preaquisition Patient body mass index 26.2-34.7
    Preaquisition Patient gender Female
    Male
    Preaquisition Patient age 30-60 years
    Preaquisition Diagnosis/ patient condition Average 5 h nightly sleep
    Average 8 h nightly sleep
    Average 9.5 h nightly sleep
    5-9.5 h average nightly sleep

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