Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.

Author(s): Taheri S, Lin L, Austin D, Young T, Mignot E

Publication: PLoS Med, 2004, Vol. 1, Page e62

PubMed ID: 15602591 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of average nightly sleep, BMI, age and gender on metabolic markers in serum. Serum was stored at -70 degrees C for an unspecified time.

   Summary of Findings:

   There was a curvilinear relationship between average nightly sleep and BMI, with the lowest BMI found in individuals with an average of 7.7 h of nightly sleep. Ghrelin decreased and leptin increased with increasing average nightly sleep. Ghrelin, leptin, adiponectin levels were higher and insulin and glucose levels were lower in females than males. Further an increase in BMI correlated with a decrease in ghrelin and adiponectin levels and an increase in leptin, insulin and glucose levels. When average nightly sleep decreased from 8 h to 5 h, there was a 15.5% decrease in leptin, a 14.9% increase in ghrelin, and an increase in average BMI from 31.3 to 32.4. The authors report that storage of serum at -70 degrees C had a small effect on some variables, but no details were provided. Adiponectin and glucose increased with patient age.

   Biospecimens

   • Bodily Fluid - Serum
   • Bodily Fluid - Blood

   Preservative Types

   • Frozen

   Diagnoses:

   • Not specified
   • Hypertension
   • Diabetes Type 2

   Platform:

   Analyte	Technology Platform
   Carbohydrate	Clinical chemistry/auto analyzer
   Protein	ELISA
   Protein	Radioimmunoassay
   Peptide	Radioimmunoassay
   Lipid	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Patient body mass index	26.2-34.7
   Preaquisition	Patient gender	Female Male
   Preaquisition	Patient age	30-60 years
   Preaquisition	Diagnosis/ patient condition	Average 5 h nightly sleep Average 8 h nightly sleep Average 9.5 h nightly sleep 5-9.5 h average nightly sleep

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