Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Author(s): Taheri S, Lin L, Austin D, Young T, Mignot E
Publication: PLoS Med, 2004, Vol. 1, Page e62
PubMed ID: 15602591 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
The purpose of this study was to determine the effects of average nightly sleep, BMI, age and gender on metabolic markers in serum. Serum was stored at -70 degrees C for an unspecified time.
Summary of Findings:
There was a curvilinear relationship between average nightly sleep and BMI, with the lowest BMI found in individuals with an average of 7.7 h of nightly sleep. Ghrelin decreased and leptin increased with increasing average nightly sleep. Ghrelin, leptin, adiponectin levels were higher and insulin and glucose levels were lower in females than males. Further an increase in BMI correlated with a decrease in ghrelin and adiponectin levels and an increase in leptin, insulin and glucose levels. When average nightly sleep decreased from 8 h to 5 h, there was a 15.5% decrease in leptin, a 14.9% increase in ghrelin, and an increase in average BMI from 31.3 to 32.4. The authors report that storage of serum at -70 degrees C had a small effect on some variables, but no details were provided. Adiponectin and glucose increased with patient age.
- Not specified
- Diabetes Type 2
Analyte Technology Platform Carbohydrate Clinical chemistry/auto analyzer Protein ELISA Protein Radioimmunoassay Peptide Radioimmunoassay Lipid Clinical chemistry/auto analyzer
Classification Pre-analytical Factor Value(s) Preaquisition Patient body mass index 26.2-34.7
Preaquisition Patient gender Female
Preaquisition Patient age 30-60 years
Preaquisition Diagnosis/ patient condition Average 5 h nightly sleep
Average 8 h nightly sleep
Average 9.5 h nightly sleep
5-9.5 h average nightly sleep