A comparison of peripheral and centrally collected cyclosporine a blood levels in pediatric patients undergoing stem cell transplant.
Author(s): Senner AM, Johnston K, McLachlan AJ
Publication: Oncol Nurs Forum, 2005, Vol. 32, Page 73-7
PubMed ID: 15660145 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
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Study Purpose
The purpose of this study was to determine the effects of central versus peripheral blood collection on the measurement of CSA concentrations in pediatric patients undergoing stem cell transplants and CSA therapy. The paired specimens were not taken simultaneously, but the time lapse between sampling was recorded (0-50 min, average 16.3 min), and CSA blood concentration was mathematically corrected for sampling time based on the half-life of CSA and dosing schedules.
Summary of Findings:
CSA concentrations were not significantly different between central venous catheter specimens and peripheral specimens (finger prick or venipuncture).
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Neoplastic - Leukemia
- Other diagnoses
Platform:
Analyte Technology Platform Small molecule Immunoassay Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Preaquisition Diagnosis/ patient condition Hematologic disorder
Inborn error of metabolism
Primary immunodeficiency
Histiocytic disorder
Biospecimen Acquisition Anatomical location of blood draw Capillary
Central vein
Peripheral vein