Do we need time adjusted mean platelet volume measurements?

Author(s): Lancé MD, van Oerle R, Henskens YM, Marcus MA

Publication: Lab Hematol, 2010, Vol. 16, Page 28-31

PubMed ID: 20858586 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of anticoagulant type and room temperature storage on MPV and mean platelet count. While the authors do not explicitly state it, storage was assumed to be at room temperature.

   Summary of Findings:

   While initial MPV was higher in EDTA specimens than citrated specimens (8.0 fL versus 7.0 fL, p=0.0001), MPV increased with storage of either type of specimen (p=0.0001, both). Further, the rapid phase of increase in MPV in citrated specimens was between 0 and 60 minutes of storage, but in EDTA specimens, the rapid increase continued until 120 min. While mean platelet count decreased linearly with storage duration in citrated specimens (p=0.0001), storage did not affect mean platelet count in EDTA anticoagulated specimens. There was no correlation between MPV and platelet count. The authors determined the reference range for MPV should be 7.2-10.8 fL in EDTA anticoagulated specimens and 6.1-9.5 fL in citrated specimens.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal

   Platform:

   Analyte	Technology Platform
   Cell count/volume	Hematology/ auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Storage	Thaw temperature/condition	0 min 30 min 60 min 90 min 120 min 150 min 180 min 210 min 240 min
   Biospecimen Acquisition	Anticoagulant	Citrate EDTA

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