Central venous catheters versus peripheral veins for sampling blood levels of commonly used drugs.

Author(s): Shulman RJ, Ou C, Reed T, Gardner P

Publication: JPEN J Parenter Enteral Nutr, 1998, Vol. 22, Page 234-7

PubMed ID: 9661125 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of drug administration method and collecting blood from a central venous catheter versus anticubital venipuncture on therapeutic drug levels in pediatric patients. Peripheral and central blood specimens were collected within 5 minutes of one another.

   Summary of Findings:

   No clinically significant differences between central and peripheral blood specimens were found in amikacin, gentamycin, tobramycin, vancomycin and oral cyclosporine levels. In contrast, when cyclosporine was administered by IV, more than 2 fold higher concentrations were measured in central blood compared to peripheral blood (p=0.034).

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Not specified

   Platform:

   Analyte	Technology Platform
   Small molecule	Clinical chemistry/auto analyzer
   Small molecule	Immunoassay

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Other drugs	Amikacin Gentamycin Tobramycin Vancomycin Cyclosporine
   Preaquisition	Patient age	Pediatric patient
   Biospecimen Acquisition	Anatomical location of blood draw	Anticubital vein Central vein

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