Positive Association Between 25-Hydroxyvitamin D and C-Reactive Protein is Confounded by Hormonal Contraceptive Use.

Author(s): García-Bailo B, Josse AR, Jamnik J, Badawi A, El-Sohemy A

Publication: J Womens Health (Larchmt), 2013, Vol. 22, Page 417-25

PubMed ID: 23659482 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of patient HC use, ethnicity, and gender on levels of CRP and 25(OH)D in plasma.

   Summary of Findings:

   The levels of 25(OH)D and CRP in plasma were significantly higher among specimens from women who used HC than women who did not use HC (p=0.26 and p<0.0001, respectively) and were also higher than levels found in specimens from men (both p<0.0001). Plasma from Caucasian and South Asian men contained intermediate levels of CRP compared to specimens from women HC users and non-users while plasma from East Asian men contained CRP levels that were not statistically different from women not taking HC. 25(OH)D levels were very weakly correlated with CRP levels, but after accounting for HC use and dose, there were no associations between levels of the two analytes, revealing that HC use is a confounding variable in the association between 25(OH)D and CRP levels in plasma.

   Biospecimens

   • Bodily Fluid - Plasma
   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal

   Platform:

   Analyte	Technology Platform
   Protein	Clinical chemistry/auto analyzer
   Small molecule	HPLC-MS

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Patient race	Caucasian East Asian South Asian
   Preaquisition	Other drugs	< 1 mg hormonal contraceptives 1 mg or more hormonal contraceptives No hormonal contraceptives
   Preaquisition	Patient gender	Female Male

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