Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Diagnostic yield of MR-guided liver biopsies compared with CT- and US-guided liver biopsies.

Author(s): Schmidt AJ, Kee ST, Sze DY, Daniel BL, Razavi MK, Semba CP, Dake MD

Publication: J Vasc Interv Radiol, 1999, Vol. 10, Page 1323-9

PubMed ID: 10584646 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   This study compared the diagnostic sensitivity, specificity, and accuracy of MR-, CT- and US-guided liver biopsies. Sixty-four MR-guided biopsies were performed on 60 patients with lesions difficult to visualize by CT or US using an 18-gauge (G) stabilization needle and a 21-G aspiration needle. CT-guided biopsies (30 patients) and US-guided biopsies (18 patients) were performed using a 19-G stabilization needle and a 21-G aspiration or 20-G core biopsy needle. The biopsy processing and analysis methods used were not discussed. The mean sizes of the lesions biopsied under the three different guidance methods were comparable. 

   Summary of Findings:

   MR-, CT-, and US-guided liver biopsies had comparable sensitivity (75%, 77% and 79%, respectively), specificity (100%, all), and accuracy (80%, 80% and 83%, respectively). A comparable number of false negatives occurred in a comparable number of MR-, CT-, and US-guided biopsies (13/64, 6/30 and 3/18, P=0.96). A significantly lower mean number of passes were conducted for US-guided biopsies (4.4) than CT (6.8, P=0.01), but the mean number of passes were comparable for MR-guided (5.3) biopsies and US- or CT- guided biopsies.

   Biospecimens

   • Tissue - Liver
   • Cell - Liver

   Preservative Types

   • Other Preservative
   • Ethanol

   Diagnoses:

   • Neoplastic - Benign
   • Neoplastic - Sarcoma
   • Neoplastic - Lymphoma
   • Neoplastic - Carcinoma

   Platform:

   Analyte	Technology Platform
   Morphology	Light microscopy

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Method of cell acquisition	MR-guided biopsy CT-guided biopsy US-guided biopsy

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