Procoagulant effect of vitamin K antagonists?

Author(s): Al Dieri R, Ten Cate-Hoek A, Bloemen S, Ten Cate H, Hemker HC

Publication: J Thromb Haemost, 2011, Vol. 9, Page 2511-2

PubMed ID: 21981701 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of spiked thrombomodulin concentration and vitamin k anticoagulation therapy on thrombin generation. All tests were carried out in platelet poor plasma in the presence of 5 pM tissue factor.

   Summary of Findings:

   Increasing levels of thrombomodulin decreased thrombin generation. When patients were on vitamin k anticoagulation therapy, more thrombin was generated in the presence of 20 nM thrombomodulin than in patients not on vitamin k therapy; however, the opposite was true in the absence of thrombomodulin or in the presence of 10 nM thrombomodulin.

   Biospecimens

   • Bodily Fluid - Plasma
   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Not specified
   • Normal

   Platform:

   Analyte	Technology Platform
   Morphology	Hematology/ auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Aliquots and Components	Biospecimen components	0 nM thrombomodulin 10 nM thrombomodulin 20 nM thrombomodulin
   Preaquisition	Other drugs	None Vitamin K anticoagulation therapy

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