Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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CT guided percutaneous renal biopsy versus ultrasound guided for obtaining adequate tissue.

Author(s): Mukhtar KN, Mahmood SN, Umair SF

Publication: J Pak Med Assoc, 2012, Vol. 62, Page 880-2

PubMed ID: 23139967 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   This study compared the effects of CT- and US-guidance on the number of glomeruli obtained from renal biopsies. Biopsies were obtained using a spring-loaded 18 G needle under CT-(50 patients) or US-guidance (155 patients) by one of 2 nephrologists.  CT guidance was provided by a technician while ultrasound guidance was provided by a senior radiologist. The reasons for biopsy were unexplained renal failure, nephritic syndrome, or systemic lupus erythematosis. Adequate tissue was defined as 10-15 glomeruli and inadequate as a biopsy containing <6 glomeruli. The method of biopsy preservation and analysis was not specified.

   Summary of Findings:

   When guidance was by ultrasound, 8 of 155 specimens (5.2%) contained no glomeruli cells and 26 of 155 (16.8%) contained fewer than 5 glomeruli, but all specimens obtained under CT guidance contained more than 5 glomeruli (P<0.001). Further, the average number of glomeruli was significantly higher in biopsies obtained with CT guidance than ultrasound guidance (23.34 versus 10.28, P<0.05).

   Biospecimens

   • Tissue - Kidney

   Preservative Types

   • Ethanol

   Diagnoses:

   • Not specified
   • Other diagnoses
   • Lupus

   Platform:

   Analyte	Technology Platform
   Cell count/volume	Light microscopy

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Method of tissue acquisition	CT-guided biopsy Ultrasound-guided biopsy

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