NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis
Advanced SearchBrowse by AnalyteBrowse by Pre-analytical FactorSearch SOPsSOP Compendiums

Components of biological, including seasonal, variation in hematological measurements and plasma fibrinogen concentrations in normal humans.

Author(s): Maes M, Scharpé S, Cooreman W, Wauters A, Neels H, Verkerk R, De Meyer F, D'Hondt P, Peeters D, Cosyns P

Publication: Experientia, 1995, Vol. 51, Page 141-9

PubMed ID: 7875254 PubMed Review Paper? No

Purpose of Paper

The purpose of this paper was to determine the effects of month of collection on measurement of hematological parameters and plasma fibrinogen concentrations.

Conclusion of Paper

All hematological analytes in this study, except for hematocrit and platelet distribution width (PDW) were found to show seasonal and or cross-seasonal differences, and hematocrit showed significant monthly differences. The differences between peak and trough analyte values throughout the year were less than 8.5% in most cases, however, platelet counts and plasma fibrinogen showed higher variability throughout the year (14.4% and 28%, respectively). Importantly, mean corpuscular hemoglobin concentration (MCHC) was the only analyte that showed higher intraindividual variability than interindividual variability.

Studies

  1. Study Purpose

    The purpose of this study was to determine the effects of month of collection on measurement of hematological parameters and plasma fibrinogen concentrations. Healthy volunteers participating in this study in Belgium had extensive mental and physical health background checks and stringent guidelines for travel, stress, and use of any medication during the study.

    Summary of Findings:

    Red blood cell counts (RBC), hemoglobin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), MCHC, red blood cell distribution width (RDW), platelet counts, mean platelet volume (MPV), plateletcrit (PCT), and fibrinogen were found to show seasonal and or cross-seasonal differences. Hematocrit showed significant monthly differences, but PDW did not show seasonal or monthly differences. There were no interactions between gender, age, and season of specimen collection for any analyte. The differences between peak and trough analyte values throughout the year were less than 8.5% in most cases, however, platelet counts and plasma fibrinogen showed higher variability throughout the year (14.4% and 28%, respectively). Importantly, MCHC was the only analyte that showed higher intraindividual variability than interindividual variability.

    Biospecimens
    Preservative Types
    • None (Fresh)
    Diagnoses:
    • Normal
    Platform:
    AnalyteTechnology Platform
    Cell count/volume Hematology/ auto analyzer
    Protein Hematology/ auto analyzer
    Glycoprotein Clinical chemistry/auto analyzer
    Protein Spectrophotometry
    Pre-analytical Factors:
    ClassificationPre-analytical FactorValue(s)
    Preaquisition Patient age <35 years
    35-69 years
    Preaquisition Patient gender Female
    Male
    Biospecimen Acquisition Time of biospecimen collection November
    December
    January
    February
    March
    April
    May
    June
    July
    August
    September
    October
    View more

You Recently Viewed  

News and Announcements

  • Most Downloaded SOPs in 2024
  • New Articles on the GTEx Project are Now FREELY Available!
  • Just Published!
    • More...