Therapeutic monitoring of cyclosporine following pediatric bone marrow transplantation: problems with sampling from silicone central venous lines.

Author(s): Leson CL, Bryson SM, Giesbrecht EE, Saunders EF

Publication: DICP, 1989, Vol. 23, Page 300-3

PubMed ID: 2658375 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of blood collection method on cyclosporine concentrations in pediatric leukemia and blackfan diamond anemia patients.

   Summary of Findings:

   When cyclosporine was administered through iv line, blood obtained through CVL had 1.3-2.9 fold higher cyclosporine levels than peripheral capillary specimens, however, specimen collection method had no effect on the measurement of cyclosporine when the antibiotic was administered orally. The authors conclude that there is a problem with adsorption of cyclosporine by the silicone in the CVL during drug administration.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Neoplastic - Leukemia
   • Neoplastic - Pediatric
   • Other diagnoses

   Platform:

   Analyte	Technology Platform
   Small molecule	HPLC

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Other drugs	IV cyclosporine Oral cyclosporine
   Preaquisition	Diagnosis/ patient condition	Blackfan diamond anemia
   Biospecimen Acquisition	Anatomical location of blood draw	Peripheral capillary Central vein

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