Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Definition of microalbuminuria in first-morning and random spot urine in diabetic patients.

Author(s): Babazono T, Takahashi C, Iwamoto Y

Publication: Diabetes Care, 2004, Vol. 27, Page 1838-9

PubMed ID: 15220278 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   This study investigated the effects of collecting random spot urine rather than first-morning urine on the diagnosis of microalbumiuria in 668 diabetic patients. First-morning specimens were collected from 717 patients at home and a subsequent void (75% between 8:30 and noon) was collected after arrival in the clinic. Albumin levels were determined by radioimmunoassay (RIA) and creatinine by Jaffe’s method. Exclusion of specimens with albumin levels over 1000 mg/g resulted in the inclusion of matched specimens from 668 patients. Values below the ACR cut-off of 30–300 mg/g were defined as microalbuminuria.

   Summary of Findings:

   The albumin creatinine ratio was significantly strongly correlated between first-morning and random spot urine (r=0.871). However there was a bias between the two collections such that20% of first-morning specimens were classified as microalbuminuric, but 35% of subsequent voided specimens were classified as microalbuminuric.

   Biospecimens

   • Bodily Fluid - Urine

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Diabetes Type 2
   • Diabetes Type 1

   Platform:

   Analyte	Technology Platform
   Small molecule	Clinical chemistry/auto analyzer
   Protein	Radioimmunoassay

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Time of biospecimen collection	First morning urine Subsequent voided urine

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