Reference values for venous and capillary S100B in children.

Author(s): Astrand R, Romner B, Lanke J, Undén J

Publication: Clin Chim Acta, 2011, Vol. 412, Page 2190-3

PubMed ID: 21864523 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of patient age and gender as well as collection of capillary versus venous specimens on S100B levels in serum. Specimens were frozen at -80 degrees C until analysis.

   Summary of Findings:

   Higher S100B concentrations were found in venous serum drawn before or after anesthesia and capillary serum from younger children (age 1-2) than from 3-14 year olds (p<0.0001). In the younger age group, specimens from males had lower S100B concentrations than from females. Gender had no effect on S100B concentrations in specimens from 3-14 year olds. Capillary specimens had higher S100B concentrations than venous specimens. A statistically significant, but clinically insignificant difference in S100B concentrations was found between venous specimens drawn before and after anesthesia, with the latter having slightly lower values (p<0.0001).

   Biospecimens

   • Bodily Fluid - Serum
   • Bodily Fluid - Blood

   Preservative Types

   • Frozen

   Diagnoses:

   • Other diagnoses

   Platform:

   Analyte	Technology Platform
   Protein	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Anesthesia	Yes None
   Preaquisition	Patient gender	Female Male
   Preaquisition	Patient age	1-2 y 3-14 y
   Preaquisition	Diagnosis/ patient condition	Undergoing elective surgery
   Biospecimen Acquisition	Anatomical location of blood draw	Capillary Vein

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