Blood gas analysis: POCT versus central laboratory on samples sent by a pneumatic tube system.

Author(s): Zaman Z, Demedts M

Publication: Clin Chim Acta, 2001, Vol. 307, Page 101-6

PubMed ID: 11369343 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of PTS transport and blood gas analyzer type on the measurement of blood gas in specimens from patients with lung diseases. Specimens were analyzed at bedside using the IL blood gas analyzer and then sent at room temperature through a PTS and reanalyzed on the Corning 288 blood gas analyzer. This second analysis occurred an average of 13.3 min later (<10 min transport) in specimens from the lung function laboratory (LFL) and 20.2 min (<4 min transport) later in specimens from the pneumology ward.

   Summary of Findings:

   After PTS transport, specimens from the LFL had a 0.0012 increase in pH and a 0.29 mm mercury (Hg) increase in pCO2 compared to specimens analyzed at the patient bedside. The average pO2 in specimens from patients in the LFL undergoing a 100% oxygen (O2) test was 446 mm Hg when analyzed in the LFL and 346 mm Hg after PTS transport to the central laboratory. Prior to the 100% O2 test, LFL patient specimens contained no air bubbles, had a bedside PO2 of 41-107 mm Hg, and showed an average decrease in PO2 of 2.4 mm Hg after PTS transport to the central laboratory. Specimens from the pneumology ward frequently had air bubbles (68%), and after PTS transport, had average increases in pH of 0.012, decreases in pCO2 of 1.64 mm Hg, and increases in PO2 of 12.93 mm Hg (initially 37-183 mm Hg) compared to specimens that were analyzed immediately. Importantly, the effects attributed to PTS transport cannot be distinguished from those due to use of different analyzers or delayed analysis.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Other diagnoses

   Platform:

   Analyte	Technology Platform
   Gas	Clinical chemistry/auto analyzer
   Small molecule	pH

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Storage	Within hospital transportation method	Not transported Pneumatic tube system
   Storage	Specimen transport duration/condition	0 min <4 min <10 min Air bubbles No air bubbles
   Preaquisition	Diagnosis/ patient condition	Lung disease
   Clinical chemistry/auto analyzer Specific	Technology platform	IL blood gas analyzer Corning 288 blood gas analyzer

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