Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Trace metal determinations in blood obtained in evacuated collection tubes.

Author(s): Williams DM

Publication: Clin Chim Acta, 1979, Vol. 99, Page 23-9

PubMed ID: 498541 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of collection container tube on copper, lead and zinc in serum and plasma from normal volunteers and cancer patients.

   Summary of Findings:

   The type of collection container did not affect copper or iron levels in serum or plasma. In contrast, zinc levels were as much as 2.5 fold higher when specimens were collected in Vacutainer tubes rather than glass. However, zinc levels in serum collected in the "metal free" Vacutainers were only 10% higher (p<0.01) than specimens collected in glass tubes, and there was a strong correlation between the values (r=0.973).

   Biospecimens

   • Bodily Fluid - Plasma
   • Bodily Fluid - Serum
   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal
   • Neoplastic

   Platform:

   Analyte	Technology Platform
   Electrolyte/Metal	Atomic absorption spectroscopy

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Aliquots and Components	Blood and blood products	Plasma Serum
   Biospecimen Acquisition	Type of collection container/solution	Acid-washed glass Plain (red) Vacutainer Lead free (amber) Vacutainer Heparinized (green) Vacutainer Metal-free (blue) Vacutainer

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