Diurnal plasma concentrations of natriuretic propeptides in healthy young males.
Author(s): Goetze JP, Jørgensen HL, Sennels HP, Fahrenkrug J
Publication: Clin Chem, 2012, Vol. 58, Page 789-92
PubMed ID: 22282468 PubMed Review Paper? No
Purpose of Paper
The purpose of this paper was to determine the effects of time of blood draw on pro-atrial natriuretic peptide (proANP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and pro-C-type natriuretic peptide (proCNP) in plasma.
Conclusion of Paper
ProANP, but not NT-proBNP or proCNP, showed a diurnal pattern of variation in plasma. The lowest levels were measured in the late afternoon, and the highest levels were measured at night.
Studies
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Study Purpose
The purpose of this study was to determine the effects of time of blood draw on proANP, NT-proBNP, and proCNP in plasma. Details surrounding patient posture during blood collection (night versus day), processing, and storage before analysis are not provided.
Summary of Findings:
ProANP, but not NT-proBNP or proCNP, showed a diurnal pattern of variation in plasma. The lowest levels were measured in the late afternoon, and the highest levels were measured at night.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Normal
Platform:
Analyte Technology Platform Peptide Clinical chemistry/auto analyzer Peptide Radioimmunoassay Peptide Immunoassay Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Time of biospecimen collection 9:00 am
12:00 pm
3:00 pm
6:00 pm
9:00 pm
12:00 am
3:00 am
6:00 am