Stability of NT-proBNP in serum specimens collected in Becton Dickinson Vacutainer (SST) tubes.
Author(s): Dasgupta A, Chow L, Tso G, Nazareno L
Publication: Clin Chem, 2003, Vol. 49, Page 958-60
PubMed ID: 12765995 PubMed Review Paper? No
Purpose of Paper
The purpose of this paper was to determine the effects of storing serum in serum separator tubes (SST) or plain tubes at room temperature and then 4 degrees C on levels of N-terminal fragment proB-type natriuretic peptide (NT-proBNP).
Conclusion of Paper
NT-proBNP levels were not significantly affected by tube type or up to 48 h of storage.
Studies
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Study Purpose
The purpose of this study was to determine the effects of storing serum from healthy volunteers in SST or plain tubes or storing serum from patients with suspected cardiac problems in SST tubes on NT-proBNP levels. Specimens were stored at room temperature for the first 5 h and then transferred to 4 degrees C.
Summary of Findings:
NT-proBNP levels were not significantly affected by storing serum in SST or plain tubes for up to 48 h.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Not specified
- Normal
- Cardiovascular Disease
Platform:
Analyte Technology Platform Peptide Clinical chemistry/auto analyzer Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Storage Storage duration <1 h
2 h
5 h
24 h
48 h
Storage Type of storage container SST
Plain tube
Biospecimen Acquisition Type of collection container/solution SST
Plain tube