NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis

Plastic vs glass SST evacuated serum-separator blood-drawing tubes for endocrinologic analytes.

Author(s): Reinartz JJ, Ramey ML, Fowler MC, Killeen AA

Publication: Clin Chem, 1993, Vol. 39, Page 2535-6

PubMed ID: 8252733 PubMed Review Paper? No

Purpose of Paper

The purpose of this paper was to determine the effects of collection tube type on eleven endocrinologic analytes in blood specimens.

Conclusion of Paper

No significant differences were observed between plastic and glass serum separator tubes (SST). Blood specimens collected in plain glass had lower dehydroepiandrosterone sulfate (DHEAS) (p=0.01) and higher estradiol (p=0.04), but the authors were unsure if the changes were clinically significant.

Studies

  1. Study Purpose

    The purpose of this study was to compare 11 endocrinologic endpoints in blood collected in plastic versus glass SST and in plain versus SST glass tubes. Aldosterone, cortisol, DHEAS, estradiol, progesterone, 17-OH progesterone, free and total testosterone, thyroid hormone binding ratio, thyroxine and triiodothyronine were quantified for this study. Serum specimens were stored at -25 degrees C for less than 2 weeks prior to analysis.

    Summary of Findings:

    No significant differences were observed between plastic and glass SST tubes. Blood specimens collected in plain glass had lower DHEAS (p=0.01) and higher estradiol (p=0.04), but the authors were unsure if the changes were clinically significant.

    Biospecimens
    Preservative Types
    • Frozen
    Diagnoses:
    • Normal
    Platform:
    AnalyteTechnology Platform
    Steroid Radioimmunoassay
    Peptide Radioimmunoassay
    Peptide Immunoassay
    Steroid Immunoassay
    Steroid Equilibrium dialysis
    Pre-analytical Factors:
    ClassificationPre-analytical FactorValue(s)
    Biospecimen Acquisition Type of collection container/solution Plain glass tube
    Vacutainer SST tube (serum separator glass)
    Vacutainer plus SST tube (plastic serum separator)

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