Normal variation of plasma lipoproteins: postural effects on plasma concentrations of lipids, lipoproteins, and apolipoproteins.

Author(s): Miller M, Bachorik PS, Cloey TA

Publication: Clin Chem, 1992, Vol. 38, Page 569-74

PubMed ID: 1533184 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine if patient posture during blood draw (standing, sitting, supine) affects plasma lipid, lipoprotein, and cholesterol levels.

   Summary of Findings:

   Total and HDL cholesterol, lipid, lipoprotein, and apolipoprotein plasma levels decreased within 5 minutes of the subject changing postural position from standing to supine, with levels stabilizing after 20 minutes with a 7-12% reduction. Triglyceride levels decreased significantly 20 minutes after the postural change and stabilized after 40 min with a 17% reduction. Levels returned to near baseline within 10-20 minutes or 40 minutes after the subject returned to a standing position for total cholesterol, apolipoproteins, triglycerides, or lipoproteins, respectively. Similar changes and timing, although less robust, were observed when the subject changed from a standing to a sitting posture.

   Biospecimens

   • Bodily Fluid - Plasma
   • Bodily Fluid - Blood

   Preservative Types

   • Other Preservative

   Diagnoses:

   • Not specified

   Platform:

   Analyte	Technology Platform
   Steroid	Clinical chemistry/auto analyzer
   Lipid	Clinical chemistry/auto analyzer
   Lipoprotein	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Storage	Storage temperature	4 degrees C
   Biospecimen Acquisition	Patient posture	Sitting Standing Supine

   View more