Effectiveness of sodium fluoride as a preservative of glucose in blood.

Author(s): Chan AY, Swaminathan R, Cockram CS

Publication: Clin Chem, 1989, Vol. 35, Page 315-7

PubMed ID: 2914384 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of tube additive and storage at room temperature on glucose concentrations in blood and plasma from diabetic and non-diabetic subjects.

   Summary of Findings:

   When blood was collected and stored in tubes containing fluoride, glucose concentrations in blood and plasma declined in the first 4 h, but then remained stable for at least three days. In whole blood and plasma collected and stored in tubes containing heparin, a similar decrease in glucose concentration occurred in the first hour, but while glucose in fluoride containing specimens stabilized after 4 h, glucose in heparin containing specimens continued to decline rapidly.

   Biospecimens

   • Bodily Fluid - Blood
   • Bodily Fluid - Plasma

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Not specified
   • Diabetes Type 2

   Platform:

   Analyte	Technology Platform
   Carbohydrate	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Anticoagulant	Sodium fluoride Heparin
   Biospecimen Aliquots and Components	Blood and blood products	Plasma Whole blood
   Storage	Time at room temperature	0 min 15 min 30 min 45 min 1 h 1 h 15 min 1 h 30 min 1 h 45 min 2 h 4 h 24 h 48 h 72 h
   Biospecimen Aliquots and Components	Centrifugation	Centrifugation delays investigated

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