Effect of use of gel-barrier sampling tubes on determination of some antiepileptic drugs in serum.

Author(s): Bergqvist Y, Eckerbom S, Funding L

Publication: Clin Chem, 1984, Vol. 30, Page 465-6

PubMed ID: 6697500 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of storage of serum in contact with a gel separator on the measurement of therapeutic drug levels. Both patient blood and spiked drug-free serum specimens were included.

   Summary of Findings:

   When serum specimens were collected in gel separation tubes, there were decreases in concentrations of phenobarbital, phenytoin and carbamezapine. The concentrations of all three drugs decreased further with storage of serum in SST. In addition, the concentration of carbamezapine decreased with storage in AutoSep tubes. Therapeutic drug levels were not affected by storage in Venoject tubes.

   Biospecimens

   • Bodily Fluid - Serum

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Not specified
   • Normal

   Platform:

   Analyte	Technology Platform
   Small molecule	LC-MS or LC-MS/MS

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Storage	Storage duration	1 day 3 days 7 days
   Storage	Storage temperature	4 degrees C
   Storage	Type of storage container	Venoject tube Serum separator tubes AutoSep tube Microvette tube

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