The concentration of high-sensitivity troponin I, galectin-3 and NT-proBNP substantially increase after a 60-km ultramarathon.

Author(s): Salvagno GL, Schena F, Gelati M, Danese E, Cervellin G, Guidi GC, Lippi G

Publication: Clin Chem Lab Med, 2014, Vol. 52, Page 267-72

PubMed ID: 24088611 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of strenuous exercise prior to specimen collection on the concentrations of TnI, galectin-3, and NT-proBNP in serum specimens from 18 trained athletes completing a 60 km ultramarathon. Serum was frozen at -70 degrees C until analysis.

   Summary of Findings:

   Levels of TnI, galectin-3, and NT-proBNP were all significantly increased when specimens were collected within 10 minutes of volunteers running an ultramarathon compared to baseline levels measured in specimens obtained before volunteers ran. Levels of all three analytes were still significantly increased from baseline among the 5 specimens obtained from volunteer athletes 1 hour post-ultramarathon, but NT-proBNP and galectin-3 had begun to decrease compared to levels in specimens obtained 10 min post-ultramarathon. Significant differences in the percentages of specimens exceeding diagnostic thresholds were observed between baseline levels and 10 min post-ultramarathon levels for NT-proBNP and galectin-3, but not TnI.

   Biospecimens

   • Bodily Fluid - Serum
   • Bodily Fluid - Blood

   Preservative Types

   • Frozen

   Diagnoses:

   • Normal

   Platform:

   Analyte	Technology Platform
   Protein	Clinical chemistry/auto analyzer
   Peptide	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Time of biospecimen collection	Pre-ultramarathon <10 min post-ultramarathon 1 h post-ultramarathon

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