Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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The order of draw: myth or science?

Author(s): Salvagno G, Lima-Oliveira G, Brocco G, Danese E, Guidi GC, Lippi G

Publication: Clin Chem Lab Med, 2013, Vol. 51, Page 2281-5

PubMed ID: 23846149 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of draw order on potassium, sodium, calcium, magnesium, and phosphorus in serum from tubes collected before and after K2EDTA or sodium citrate tubes. 115 sets of specimens from healthy patients and those on oral anticoagulant therapy were included in this study. Serum was collected into Venosafe serum tubes containing clot activator and gel separator.

   Summary of Findings:

   There were no statistically significant differences in any of the measured analytes between serum tubes collected first and those collected third, after collection of a second specimen in either a K2EDTA or a sodium citrate tube.

   Biospecimens

   • Bodily Fluid - Serum
   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal
   • Other diagnoses

   Platform:

   Analyte	Technology Platform
   Electrolyte/Metal	Clinical chemistry/auto analyzer
   Small molecule	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Diagnosis/ patient condition	Healthy On oral anticoagulants
   Biospecimen Aliquots and Components	Aliquot sequential collection	1st collection 3rd collection
   Biospecimen Acquisition	Type of collection container/solution	Serum tube with gel separator and clot activator K2EDTA tube Sodium citrate tube

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