Interindividual variability of hemolysis in plasma samples during pneumatic tube system transport.
Author(s): Gomez-Rioja R, Fernandez-Calle P, Alcaide MJ, Madero R, Oliver P, Iturzaeta JM, Buno A
Publication: Clin Chem Lab Med, 2013, Vol. 51, Page e231-3
PubMed ID: 23633466 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
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Study Purpose
The purpose of this study was to determine the effects of PTS transport on levels of LDH, potassium, AST, and hemolysis index in lithium-heparin plasma specimens. All blood specimens were transported in carriers with foam lining and data loggers, with aliquots removed after each leg of the trip and all specimens centrifuged simultaneously. TSSAC was calculated from the data loggers included in the PTS carrier.
Summary of Findings:
The TSSAC was strongly correlated with LDH (r=0.73) and modestly correlated with the hemolysis index (r=0.649), and levels of AST (r=0.56), and potassium (r=0.53); however, there was considerable interindividual variability in the susceptibility to TSSAC. Further, clinically significant changes in LD were first identified with a TSSAC of 0.69 g x 10^3 which corresponded to a single PTS trip in the tested system. The safe threshold for the remaining analytes allowed for multiple PTS trips in the system under study, but due to interindividual variability in susceptibility and differences between PTS in different locations, the authors urge caution.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Normal
Platform:
Analyte Technology Platform Electrolyte/Metal Clinical chemistry/auto analyzer Protein Clinical chemistry/auto analyzer Cell count/volume Spectrophotometry Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Storage Within hospital transportation method Hand-delivered
Pneumatic tube system
Storage Specimen transport duration/condition Transported once
Transported twice
Transported three times
Transported four times