Establishing reference intervals for LDL subfractions in a Korean population using the Lipoprint LDL system.

Author(s): Huh HJ, Park BT, Lee SY, Kang ES, Park HD

Publication: Clin Chem Lab Med, 2013, Vol. 51, Page e179-82

PubMed ID: 23492560 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of patient gender and age on LDL particle size and its associations with other biomarker levels. Blood specimens from 242 healthy Koreans and an additional 100 Korean patients with an undesirable lipid status were used in this study.

   Summary of Findings:

   A significant negative correlation was observed between the average LDL particle size and the apoplipoprotein B/LDL ratio in blood specimens from healthy individuals. Specimens from healthy men and those older than 50 years of age had significantly smaller mean LDL particle sizes and significantly higher percentages of sdLDL than women and those 50 years old and younger, respectively. Specimens from individuals with an undesirable lipid status had significantly smaller mean LDL particle sizes and significantly higher mean sdLDL% than specimens from healthy individuals. The authors report that the reference values they found for LDL particle size and sdLDL% in the Korean population were higher than those reported previously for a Caucasian population.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal
   • Other diagnoses

   Platform:

   Analyte	Technology Platform
   Lipoprotein	Electrophoresis

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Patient gender	Female Male
   Preaquisition	Diagnosis/ patient condition	Undesirable lipid status Desirable lipid status
   Preaquisition	Patient age	50 years old or younger Over 50 years old
   Preaquisition	Biomarker level	A range of triglyceride levels A range of cholesterol levels A range of glucose levels A range of glycated hemoglobin levels A range of apolipoprotein B levels
   Preaquisition	Patient race	Korean Caucasian

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