Variation of serum and urinary neutrophil gelatinase associated lipocalin (NGAL) after strenuous physical exercise.
Author(s): Lippi G, Sanchis-Gomar F, Salvagno GL, Aloe R, Schena F, Guidi GC
Publication: Clin Chem Lab Med, 2012, Vol. 50, Page 1585-9
PubMed ID: 22962218 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
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Study Purpose
The purpose of this study was to determine the effects of strenuous exercise in the form of an ultramarathon on the levels of creatinine and NGAL in serum and the correlation with urine levels.
Summary of Findings:
Serum creatinine increased by an average of 38% after volunteers completed running an ultramarathon, and NGAL increased by 1.6-fold compared to levels measured in serum collected prior to when volunteers ran. There were no significant correlations found between pre-exercise levels of serum and urine NGAL or between post-exercise levels of serum and urine NGAL. However, there was a strong correlation between the post-exercise changes in serum creatinine levels and those in serum NGAL (r=0.813).
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Normal
Platform:
Analyte Technology Platform Small molecule Clinical chemistry/auto analyzer Protein Clinical chemistry/auto analyzer Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Time of biospecimen collection Pre-exercise
Post-exercise
Biospecimen Acquisition Biospecimen location Serum
Urine
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Study Purpose
The purpose of this study was to determine the effects of strenuous exercise in the form of an ultramarathon on the levels of creatinine and NGAL in urine.
Summary of Findings:
Urine creatinine increased by an average of 78% in specimens collected after the ultramarathon, and urine NGAL increased by 7.7-fold compared to levels measured in urine collected prior to the ultramarathon.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Normal
Platform:
Analyte Technology Platform Small molecule Clinical chemistry/auto analyzer Protein Clinical chemistry/auto analyzer Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Time of biospecimen collection Pre-exercise
Post-exercise