Preanalytical effects of pneumatic tube transport on routine haematology, coagulation parameters, platelet function and global coagulation.

Author(s): Wallin O, Söderberg J, Grankvist K, Jonsson PA, Hultdin J

Publication: Clin Chem Lab Med, 2008, Vol. 46, Page 1443-9

PubMed ID: 18844500 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of aspirin therapy and PTS transport on 6 coagulation and 19 cell count parameters in venous blood from healthy subjects. Specimens transported by PTS made a round trip to and from the transfer system 500 m away (155 sec) prior to analysis. Blood was anticoagulated with EDTA or citrate.

   Summary of Findings:

   Small differences in reticulocytes (-3.6%, p=0.012), high fluorescent reticulocytes (-50%, p=0.003), platelet counts (1.2%, p=0.006), platelet distribution width (-2.5%, p=0.008), and time to clot formation (-16%, p=0.037) were observed when specimens from subjects not taking aspirin were transported by PTS rather than analyzed immediately. In specimens collected after patients had taken aspirin for 1 week, reticulocytes (-8.1%, p=0.009), high fluorescent reticulocytes (-52%, p=0.034), reticulocyte hemoglobin equivalent (-1.4%, p=0.001), platelet distribution width (-0.8%, p=0.047), antithrombin percent (0.7%, p=0.026), coagulation index (60%, p=0.043), and time to clot formation (-22%, p=0.043) were significantly different in PTS-transported specimens compared to specimens that were not transported. The closure time (CT) using the collagen membrane coated with epinephrine (CEPI) cartridge showed a large difference between specimens from subjects not taking aspirin transported by PTS rather than not transported , but the differences were driven by a few individuals with large increases or decreases. The CT using the adenine diphosphate (ADP) cartridge (CADP) was not different in specimens transported by PTS compared to specimens not transported.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal

   Platform:

   Analyte	Technology Platform
   Cell count/volume	Hematology/ auto analyzer
   Glycoprotein	Hematology/ auto analyzer
   Morphology	Hematology/ auto analyzer
   Peptide	Hematology/ auto analyzer
   Protein	Hematology/ auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Storage	Within hospital transportation method	Not transported Pneumatic tube system
   Preaquisition	Other drugs	Prior to aspirin therapy After 1 week of aspirin therapy

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