The age related association is more pronounced for cystatin C estimated GFR than for creatinine estimated GFR in primary care patients.

Author(s): Helmersson-Karlqvist J, Flodin M, Hansson LO, Larsson A

Publication: Clin Biochem, 2013, Vol. 46, Page 1761-3

PubMed ID: 23872205 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of patient age and gender on the eGFR calculated from serum cystatin C or plasma creatinine levels. Specimens were obtained from 1552 primary care patients.

   Summary of Findings:

   For all three calculation methods, reduced eGFR was observed more often as patient age increased. eGFR calculations based on cystatin C levels were modestly associated with age (r2=0.43), while calculations based on creatinine levels (eGFR(MDRD) and eGFR(CKD-EPI)) were weakly associated with age (r2=0.23 and 0.37, respectively). Patient gender did not have a significant effect on calculated eGFR.

   Biospecimens

   • Bodily Fluid - Serum
   • Bodily Fluid - Plasma
   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Not specified

   Platform:

   Analyte	Technology Platform
   Small molecule	Clinical chemistry/auto analyzer
   Protein	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Aliquots and Components	Blood and blood products	Plasma Serum
   Preaquisition	Patient age	18-40 years 41-60 years 61-80 years >80 years
   Preaquisition	Patient gender	Female Male
   Clinical chemistry/auto analyzer Specific	Analytical algorithm	eGFR(MDRD) eGFR(CKD-EPI) eGFR(Cystatin C)

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