Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial.

Author(s): Kalpatthi R, Thompson B, Lu M, Wang WC, Patel N, Kutlar A, Howard T, Luchtman-Jones L, Miller ST

Publication: Clin Biochem, 2013, Vol. 46, Page 278-81

PubMed ID: 23123915 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of shipping specimens overnight to a central laboratory on CBC results in infants with sickle cell anemia. Two aliquots of potassium EDTA blood were collected from 167 individuals. One specimen was analyzed in the local lab while the other was shipped to the central laboratory. Specimens were shipped overnight with frozen ice packs and inserts to keep the tube upright.

   Summary of Findings:

   Local laboratory values for ANC and AMC were higher, and ALC and MCV were lower than those obtained after shipping specimens overnight to the central laboratory (p<0.0001, all). Further, the authors report the correlations between local and central values for ANC and AMC were very weak, while the correlations between local and central laboratory values for ALC and MCV were better, but the exact values were not given.

   Biospecimens

   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Other diagnoses

   Platform:

   Analyte	Technology Platform
   Cell count/volume	Hematology/ auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Diagnosis/ patient condition	Sickle cell anemia
   Storage	Between site transportation method	Mailed Not transported

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