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Comparison of 21-gauge and 22-gauge aspiration needle in endobronchial ultrasound-guided transbronchial needle aspiration: results of the American College of Chest Physicians Quality Improvement Registry, Education, and Evaluation Registry.

Author(s): Yarmus LB, Akulian J, Lechtzin N, Yasin F, Kamdar B, Ernst A, Ost DE, Ray C, Greenhill SR, Jimenez CA, Filner J, Feller-Kopman D

Publication: Chest, 2013, Vol. 143, Page 1036-43

PubMed ID: 23632441 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   This study compared the rate of specimen adequacy and diagnosis of 21- G and 22-G EBUS-TBNA. Data from 1299 patients who underwent EBUS-TBNA at six centers using 21-G (249 patients) or 22-G (995 patients) was analyzed.  Needle gauge and the use of Rapid On-Site Cytological Evaluation (ROSE) were decided by the bronchoscopist. Specimens were defined as adequate if the cytology confirmed the presence of lymphocytes or allowed for diagnosis. The cytologic methods used were not discussed.

   Summary of Findings:

   EBUS-TBNA obtained with 21-G and 22-G needles had comparable specimen adequacy (94.6% and 94.9%) and diagnosis rates (51.3% and 51.4%, respectively). When ROSE was used, the mean number of needle passes obtained per node was greater in the 22-G group than the 21-G group (4.6 versus 3.7, P<0.001) but the number of needle passes was comparable when ROSE was not used (3.2, both).  

   Biospecimens

   • Cell - Lymph Node
   • Cell - Lung

   Preservative Types

   • Other Preservative
   • Ethanol

   Diagnoses:

   • Neoplastic - Carcinoma
   • Neoplastic - Not specified
   • Neoplastic - Benign

   Platform:

   Analyte	Technology Platform
   Morphology	Light microscopy

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Needle gauge	21-G 22-G

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