BRCAPAP: feasibility of clinical BRCA testing on liquid-based cervical cytology: implications for biomarker development.
Author(s): Muller CY, Schorge JO, Tomlinson GE, Ashfaq R
Publication: Cancer Epidemiol Biomarkers Prev, 2004, Vol. 13, Page 1534-7
PubMed ID: 15342457 PubMed Review Paper? No
Purpose of Paper
This paper compared BRCA genetic screening results among case-matched blood and cervical specimens to determine the degree of concordance.
Conclusion of Paper
A concordance of 100% was observed among blood, cervical, and vaginal specimens with respect to BRCA1 and 2 mutations and polymorphisms.
Studies
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Study Purpose
This study compared BRCA genetic screening results among case-matched blood and cervical specimens to determine the degree of concordance.
Summary of Findings:
A concordance of 100% was observed among blood, cervical, and vaginal specimens with respect to BRCA1 and BRCA2 mutations and polymorphisms. Further, blood and cervical specimens generated DNA sequence of comparable quality.
Biospecimens
Preservative Types
- Other Preservative
Diagnoses:
- Other diagnoses
Platform:
Analyte Technology Platform DNA DNA sequencing Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Biospecimen location Cervix
Vagina
Blood