Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period.
Author(s): Michaud DS, Manson JE, Spiegelman D, Barbieri RL, Sepkovic DW, Bradlow HL, Hankinson SE
Publication: Cancer Epidemiol Biomarkers Prev, 1999, Vol. 8, Page 1059-64
PubMed ID: 10613337 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
-
Study Purpose
The purpose of this study was to determine if a single plasma specimen is representative of long-term sex hormone levels in premenopausal women.
Summary of Findings:
Plasma estradiol, estrone, estrone sulfate, and progesterone levels were similar among case-matched specimens collected a year apart, with intraclass correlation coefficients of 0.52-0.71.
Biospecimens
Preservative Types
- Frozen
Diagnoses:
- Not specified
Platform:
Analyte Technology Platform Steroid Radioimmunoassay Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Time of biospecimen collection Follicular phase (t=0, t=1 y)
Luteal phase (t=0, t=1 y)
-
Study Purpose
The purpose of this study was to determine if a single urine specimen is representative of long-term sex hormone levels in premenopausal women.
Summary of Findings:
Urinary steroid metabolite levels (2-hydroxyestrone, 16 alpha-hydroxyestrone) were similar in case-matched specimens collected approximately a year apart, with intraclass correlation coefficients of 0.56-0.71.
Biospecimens
Preservative Types
- Frozen
Diagnoses:
- Not specified
Platform:
Analyte Technology Platform Steroid ELISA Small molecule Clinical chemistry/auto analyzer Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Time of biospecimen collection Follicular phase (t=0, t=1 y)
Luteal phase (t=0, t=1 y)