Effect of needle size on cancer detection, pain, bleeding and infection in TRUS-guided prostate biopsies: A prospective trial.
Author(s): McCormack M, Duclos A, Latour M, McCormack MH, Liberman D, Djahangirian O, Bergeron J, Valiquette L, Zorn K
Publication: Can Urol Assoc J, 2012, Vol. 6, Page 97-101
PubMed ID: 22511415 PubMed Review Paper? No
Purpose of Paper
This paper investigated if use of 16-gauge (G) rather than 18G needles affected prostate cancer diagnosis rate or pathology.
Conclusion of Paper
Use of a 16G rather than 18G needle did not significantly affect the prostate cancer diagnosis rate or the incidence of prostatic intraepithelial neoplasia (PIN) or atypical small acinar proliferation (ASAP).
Studies
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Study Purpose
This study compared the prostate cancer diagnosis rate and pathology findings in 16G and 18G biopsies. Each of 105 patients underwent 6-core needle, TRUS-guided biopsies using both a 18G and a 16G needle by one of three pathologists. Each needle was used to biopsy the lateral peripheral zone such that one needle was used more centrally on one side and the other needle more centrally on the other side. Pathological analysis is assumed to have been done on FFPE specimens.
Summary of Findings:
Prostate cancer was diagnosed in a comparable percentage of 16G and 18G biopsies (31.4% and 36.2%, respectively, P=0.33). Needle gauge also did not affect the detection of prostatic intraepithelial neoplasia (PIN) (21.9% of 18G and 26.7% of 16G, P=0.44) or atypical small acinar proliferation (ASAP) (8.6% of 18G and 12.4% of 16G, P=42). Further, no effects of needle gauge on post-procedure bleeding, pain, or infection were found.
Biospecimens
Preservative Types
- Formalin
Diagnoses:
- Neoplastic - Benign
- Neoplastic - Carcinoma
Platform:
Analyte Technology Platform Morphology Light microscopy Morphology H-and-E microscopy Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Biospecimen Acquisition Needle gauge 16G
18G