Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Discard first tube for coagulation testing.

Author(s): Tekkesin N, Esen OB, Kilinç C, Eviyaoglu O

Publication: Blood Coagul Fibrinolysis, 2012, Vol. 23, Page 299-303

PubMed ID: 22450544 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of aliquot sequential collection on PT and APTT using specimens from patients on oral anticoagulant therapy. 2 specimens were consecutively drawn into tubes containing sodium citrate.

   Summary of Findings:

   Significant differences were found in PT, APTT, and INR between plasma from the first collection and plasma from the second collection. The differences in PT between collection tubes ranged from -15.4% to 18.2%. The differences in APTT between collection tubes ranged from -16.86% to 27.99%. And lastly, the differences in INR between first and second collection tubes ranged from -28.6% to 23.7%, and the difference in INR between the two tubes increased with increasing INR values.

   Biospecimens

   • Bodily Fluid - Plasma
   • Bodily Fluid - Blood

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Not specified

   Platform:

   Analyte	Technology Platform
   Morphology	Hematology/ auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Preaquisition	Biomarker level	INR <2 INR 2.0-3.0 INR 3.1-4.5 INR >4.5
   Biospecimen Aliquots and Components	Aliquot sequential collection	1st collection 2nd collection

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