Postmortem enzyme immunoassay for human immunodeficiency virus.
Author(s): Klatt EC, Shibata D, Strigle SM
Publication: Arch Pathol Lab Med, 1989, Vol. 113, Page 485-7
PubMed ID: 2653271 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
-
Study Purpose
The purpose of this study was to determine the effects of PMI on the detection of HIV in blood specimens. Specimens were collected at autopsy and refrigerated at 4 degrees C for 5 h-58 days.
Summary of Findings:
HIV was detected in all blood specimens from HIV positive individuals, even after a postmortem delay of 1392 h, and was not detected in blood collected from HIV negative individuals with PMIs of up to 548 h.
Biospecimens
Preservative Types
- Other Preservative
Diagnoses:
- AIDS/HIV-related
- Autopsy
- Not specified
Platform:
Analyte Technology Platform Protein Immunoassay Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Preaquisition Postmortem interval 5 h
7 h
10 h
11 h
13 h
14 h
16 h
20 h
21 h
23 h
24 h
26 h
27 h
31 h
32 h
34 h
36 h
43 h
44 h
51 h
55 h
60 h
62 h
72 h
96 h
102 h
120 h
144 h
188 h
384 h
432 h
548 h
1392 h
-
Study Purpose
The purpose of this study was to determine the effects of PMI on the detection of HIV in vitreous humor specimens. Specimens were collected at autopsy and refrigerated at 4 degrees C for 5 h to 16 days.
Summary of Findings:
HIV was detected in all vitreous humor specimens collected from HIV positive individuals 5-34 h postmortem and 11 of 16 vitreous humor specimens collected 34-384 h postmortem. HIV was not detected in vitreous humor collected from HIV negative individuals with PMIs of up to 548 h.
Biospecimens
Preservative Types
- Other Preservative
Diagnoses:
- AIDS/HIV-related
- Autopsy
- Not specified
Platform:
Analyte Technology Platform Protein Immunoassay Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Preaquisition Postmortem interval 5 h
7 h
10 h
11 h
13 h
14 h
20 h
21 h
23 h
24 h
26 h
27 h
31 h
32 h
34 h
36 h
44 h
51 h
55 h
60 h
62 h
72 h
96 h
102 h
120 h
144 h
188 h
384 h
432 h
548 h