Evaluation of the i-STAT Portable Clinical Analyzer for point-of-care blood testing in the intensive care units of a university children's hospital.
Author(s): Papadea C, Foster J, Grant S, Ballard SA, Cate JC 4th, Southgate WM, Purohit DM
Publication: Ann Clin Lab Sci, 2002, Vol. 32, Page 231-43
PubMed ID: 12175085 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
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Study Purpose
The purpose of this study was to determine the effects of analyzer type on clinical chemistry and hematology analysis of pediatric blood specimens.
Summary of Findings:
The day to day coefficient of variance (CV) using iSTAT for electrolytes, glucose, urea nitrogen and pH was less than 2% and the CV for oxygen and carbon dioxide were less than 6.5%, but the hematocrit and creatinine were highly variable with CVs of 21 and 23.6%, respectively. The CVs using iSTAT were comparable to the CVs using the VITROS or ABL analyzers for all analytes except creatinine and hematocrit which had CVs of <3% using the VITROS analyzer and <9.1% using the ABL analyzer, respectively. The different cartridges performed similarly for all of the analytes that were analyzed by multiple cartridge types. However, a follow-up study of creatinine levels found less correlation between VITROS values using a new lot of cartridges, resulting in possible clinical differences. In specimens analyzed using iSTAT, a small proportional negative bias was found for ionized calcium (iCa) and partial pressure oxygen (PO2), and a there was a positive bias for creatinine. The iSTAT analyzer was found to have good reproducibility for children under 3 months old and those over 3 months old. The authors conclude that iSTAT is suitable for clinical chemistry and hematology analysis for all analytes except creatinine.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Not specified
Platform:
Analyte Technology Platform Electrolyte/Metal Clinical chemistry/auto analyzer Gas Clinical chemistry/auto analyzer Small molecule Clinical chemistry/auto analyzer Carbohydrate Clinical chemistry/auto analyzer Small molecule pH Cell count/volume Hematology/ auto analyzer Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Clinical chemistry/auto analyzer Specific Technology platform iSTAT portable clinical analyzer
Radiometer ABL 725 blood gas analyzer
Vitros 750 chemistry analyzer
Coulter STKS hematology analyzer
Hematology/ auto analyzer Specific Technology platform iSTAT portable clinical analyzer
Coulter STKS hematology analyzer
Clinical chemistry/auto analyzer Specific Detection method EC8+ cartridge
EC6+ cartridge
G3+ cartridge
Creatinine cartridge
Preaquisition Patient age < 3 months
> 3 months