Impact of prandial status on the comparison of capillary glucose meter and venous plasma glucose measurements in healthy volunteers.

Author(s): Swaminathan A, Lunt H, Chang WS, Logan FJ, Frampton CM, Florkowski CM

Publication: Ann Clin Biochem, 2013, Vol. 50, Page 6-12

PubMed ID: 23148281 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   The purpose of this study was to determine the effects of venous versus capillary blood collection, fasting versus non-fasting collection, gender, and type of glucometer on glucose measurements in specimens from healthy volunteers (not diabetic). Following capillary collection, venous specimens were collected from the same arm, centrifuged immediately, and plasma was analyzed.

   Summary of Findings:

   Venous plasma glucose levels were lower in specimens collected 1 hour after breakfast compared to those collected after an overnight fast by an average of 0.59 mmol/L. Neither the amount of carbohydrates consumed during breakfast nor gender influenced the change in glucose levels. Overall, capillary blood contained an average glucose concentration that was 0.15 mmol/L higher than venous plasma when the FreeStyle Lite meter was used and 0.53 mmol/L higher when the Performa meter was used. When the FreeStyle Lite meter was used, the average preprandial difference between capillary and venous specimen glucose concentration was -0.52 mmol/L (venous specimens were higher), and the average postprandial difference between capillary and venous specimens was 0.81 mmol/L (capillary specimens were higher). When the Performa meter was used, the average preprandial difference was -0.13 mmol/L (venous specimens were higher), and the average postprandial difference was 1.19 mmol/L (capillary specimens were higher). The differences between capillary and venous specimen glucose concentrations in the pre- and postprandial states are significant for both meters.

   Biospecimens

   • Bodily Fluid - Blood
   • Bodily Fluid - Plasma

   Preservative Types

   • None (Fresh)

   Diagnoses:

   • Normal

   Platform:

   Analyte	Technology Platform
   Carbohydrate	Clinical chemistry/auto analyzer

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Time of biospecimen collection	After overnight fast 1 hour after breakfast
   Clinical chemistry/auto analyzer Specific	Technology platform	FreeStyle Lite Performa
   Biospecimen Aliquots and Components	Blood and blood products	Plasma Whole blood
   Preaquisition	Patient gender	Female Male
   Preaquisition	Patient diet	24.2-296.8 g carbohydrates
   Biospecimen Acquisition	Anatomical location of blood draw	Capillary Vein

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