NIH, National Cancer Institute, Division of Cancer Treatment and Diagnosis (DCTD) NIH - National Institutes of Health National Cancer Institute DCTD - Division of Cancer Treatment and Diagnosis

Stability of intact parathyroid hormone in blood samples.

Author(s): Anderson NR, Gama R

Publication: Ann Clin Biochem, 2001, Vol. 38, Page 288-9

PubMed ID: 11392510 PubMed Review Paper? No

Purpose of Paper

The purpose of this paper was to determine the effects of collecting blood into plain versus gel tubes on the measurement of intact parathyroid hormone (iPTH) in serum.

Conclusion of Paper

Serum iPTH levels were 13% higher when blood was collected into plain serum tubes rather than gel serum tubes (p<0.01).

Studies

  1. Study Purpose

    The purpose of this study was to determine the effects of collecting blood into plain versus gel tubes on the measurement of iPTH in serum from patients with chronic renal failure. Serum was separated after 20 minutes at room temperature and frozen at -20 degrees C until analysis.

    Summary of Findings:

    Serum iPTH levels were 13% higher when blood was collected into plain serum tubes rather than gel serum tubes (p<0.01). The authors hypothesize the difference may be attributable to the clot activator, the gel barrier, or both.

    Biospecimens
    Preservative Types
    • Frozen
    Diagnoses:
    • Other diagnoses
    Platform:
    AnalyteTechnology Platform
    Peptide Clinical chemistry/auto analyzer
    Pre-analytical Factors:
    ClassificationPre-analytical FactorValue(s)
    Preaquisition Diagnosis/ patient condition Chronic renal failure
    Biospecimen Acquisition Type of collection container/solution Plain serum tube
    Gel serum tube

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