Feasibility of serodiagnosis of ovarian cancer by mass spectrometry.
Author(s): West-Nørager M, Bro R, Marini F, Høgdall EV, Høgdall CK, Nedergaard L, Heegaard NH
Publication: Anal Chem, 2009, Vol. 81, Page 1907-13
PubMed ID: 19178286 PubMed Review Paper? No
Purpose of Paper
Conclusion of Paper
Studies
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Study Purpose
The purpose of this study was to determine the effects of patient age, frozen storage duration, and diagnosis of malignant versus benign ovarian tumor on the MALDI-TOF MS peak patterns in serum. Serum was stored at -80 degrees C within 6 h of blood collection.
Summary of Findings:
The authors report no patient-age dependent correlations in MALDI-TOF MS data. Duration of serum storage up to 15 months could be predicted with some degree of confidence based on peak patterns, but there was more uncertainty beyond 15 months. The authors were able to develop a model to differentiate serum MALDI-TOF MS peak patterns from patients with benign versus malignant ovarian tumors, but it did not perform as well as existing serum markers.
Biospecimens
Preservative Types
- Frozen
Diagnoses:
- Neoplastic - Benign
- Neoplastic - Carcinoma
Platform:
Analyte Technology Platform Protein MALDI-TOF MS Peptide MALDI-TOF MS Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Storage Storage duration 1-23 months
Preaquisition Patient age Mean 45 years
Mean 65 years
Preaquisition Diagnosis/ patient condition Benign
Ovarian cancer