Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Stereotactic breast biopsy: comparison of histologic underestimation rates with 11- and 9-gauge vacuum-assisted breast biopsy.

Author(s): Lourenco AP, Mainiero MB, Lazarus E, Giri D, Schepps B

Publication: AJR Am J Roentgenol, 2007, Vol. 189, Page W275-9

PubMed ID: 17954625 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   This study compared the characteristics and underestimation rate of stereotactic vacuum-assisted breast biopsies obtained with 11- and 9-gauge needles. Results from stereotactic vacuum-assisted breast biopsies obtained with an 11-gauge needle in 828 cases and with a 9-gauge needle in 395 cases were compared with those obtained by surgical resection (239 cases). All lesions were BI-RADS category 4 or 5 and lesion size was comparable between groups. It is assumed that the pathological analysis included light microscopy and H&E staining of formalin-fixed paraffin-embedded sections.

    

   Summary of Findings:

   The 11-gauge and 9-gauge biopsies had comparable rates of clusters of calcification (82% and 87%, respectively) and non-calcified lesions including masses, architectural distortion, and asymmetries (18% and 13%, respectively). Slightly, but not significantly, more specimens per lesion were obtained with an 11-gauge needle (mean of 8 specimens, range 6-24) than with a 9-gauge needle (mean of 7 specimens, range 1-20). Comparable percentages of specimens diagnosed as ADH based on biopsy with an 11- or 9-gauge needle were found to contain DCIS or invasive carcinoma after surgical resection (28.3% and 29.6%, respectively P=0.9). Similarly, surgical specimens from cases diagnosed as DCIS in the biopsy were found to contain invasive carcinoma in 28.7% of cases (35 of 122) biopsied with an 11- gauge needle and 22.7% of cases (10 of 44) biopsied with a 9-gauge needle (P=0.4). Interestingly, in cases of DCIS the rate of underestimation as ADH increased with increasing lesion size (odds ratio=1.039, P=0.03).

   Biospecimens

   • Tissue - Breast

   Preservative Types

   • Formalin

   Diagnoses:

   • Neoplastic - Benign
   • Neoplastic - Carcinoma

   Platform:

   Analyte	Technology Platform
   Morphology	H-and-E microscopy
   Morphology	Light microscopy

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Method of tissue acquisition	Vacuum assisted biopsy Surgical resection
   Biospecimen Acquisition	Needle gauge	11-gauge 9-gauge

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