Cancer Diagnosis Program | Biorepositories and Biospecimen Research Branch

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Ultrasound Guided Fine-Needle Aspiration Biopsy of Thyroid Nodules: Does Radiologist Assistance Decrease the Rate of Unsatisfactory Biopsies?

Author(s): Kaliszewski K, Zubkiewicz-Kucharska A, Wojtczak B, Strutyńska-Karpińska M, Zaleska-Dorobisz U, Leśków E

Publication: Adv Clin Exp Med, 2016, Vol. 25, Page 93-100

PubMed ID: 26935503 PubMed Review Paper? No

Purpose of Paper

Conclusion of Paper

Studies

1. Study Purpose

   This study examined the effect of assistance of a radiologist during UG-FNAB on the cellularity of the specimen and the probability that a biopsy would be adequate for diagnosis. All 453 UG-FNAB were obtained by a single surgeon from 385 patients using 0.5 mm needles and 10 cc syringes. The surgeon had the assistance of a radiologist for 9 of the 34 CT-FNA specimens and 1 of the 16 EUS-FNA specimens, but biopsy for the remaining 201 patients (241 biopsies) was performed without the assistance of a radiologist. Specimens were fixed in ethanol and evaluated by one of two cytologists.

   Summary of Findings:

   Diagnosis was achieved in a significantly higher proportion of UG-FNAB when a radiologist assisted than when the surgeon performed the biopsy alone (77.8% versus 56.8%, P<0.0001). Further, specimens obtained with the assistance of the radiologist were more likely to contain patches of cellularity (12.7% versus 2.5%) or a few cells (65.1% versus 54.4%) and more likely to contain follicular cells (22.2% versus 43.1%) (P<0.001). However, the assistance of a radiologist had no effect on the incidence of complications (bruising or hematoma).

   Biospecimens

   • Tissue - Thyroid Gland

   Preservative Types

   • Ethanol

   Diagnoses:

   • Neoplastic - Carcinoma
   • Neoplastic - Benign

   Platform:

   Analyte	Technology Platform
   Morphology	Light microscopy

   Pre-analytical Factors:

   Classification	Pre-analytical Factor	Value(s)
   Biospecimen Acquisition	Method of cell acquisition	With assistance of the radiologist Without assistance of the radiologist

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